Sermorelin: A Review of GHRH-Analogue Research
Sermorelin is the first 29 amino acids of human GHRH. What the pediatric, aging and mechanistic literature actually recorded, and where the evidence stops.
Topic
Growth-hormone secretagogues and GHRH analogues: sermorelin, tesamorelin, CJC-1295, ipamorelin and the receptor biology behind them.
5 notes in this topic
Sermorelin is the first 29 amino acids of human GHRH. What the pediatric, aging and mechanistic literature actually recorded, and where the evidence stops.
Tesamorelin is a stabilized GHRH analogue and the active ingredient of Egrifta. Its phase 3 trials, liver and cognition studies, and evidence limits.
A GHRH analog and a ghrelin-receptor agonist act on two different pituitary receptors. The literature explains why that pairing draws research interest.
Ipamorelin was designed to release GH without the cortisol and prolactin signals of older secretagogues. What the animal and human record shows.
Three classes of molecule act at three points in the growth-hormone axis. What each is, which receptor it binds, and why the distinction matters.
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